Chitin synthase inhibitor 2

Description: Chitin synthase inhibitor 2 (compound 2b) is a highly potent inhibitor of chitin synthase, with an IC50 of 0.09 mM and a K i of 0.12 mM. This compound exhibits antimicrobial activity in vitro and demonstrates synergistic or additive effects when combined with fluconazole or polyoxin B [1]. Target: Others. Smiles: N(C(C=CC(NC1=CC(C)=CC=C1)=O)=O)C2CC=3C(NC2=O)=CC=CC3