Chenodeoxycholic Acid-d4

Chenodeoxycholic Acid-d4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay20848-1 1 mg -

6 - 10 business days*

60.00€
Cay20848-5 5 mg -

6 - 10 business days*

216.00€
Cay20848-10 10 mg -

6 - 10 business days*

401.00€
 
Chenodeoxycholic acid-d4 (CDCA-d4) is intended for use as an internal standard for the... more
Product information "Chenodeoxycholic Acid-d4"
Chenodeoxycholic acid-d4 (CDCA-d4) is intended for use as an internal standard for the quantification of CDCA (Cay-10011286) by GC- or LC-MS. CDCA is a hydrophobic primary bile acid. It is formed from cholesterol in the liver via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. CDCA is a farnesoid X receptor (FXR) agonist that binds to FXRs in a TR-FRET assay (EC50 = 13 µM) and induces FXR transactivation in a reporter assay. It induces transcription of the gene encoding the Nrf2 target glutamate cysteine ligase (GCL) in primary hepatocytes and HepG2 cells when used at concentrations ranging from 25 to 100 µM.Formal Name: 3alpha,7alpha-dihydroxy-5beta-cholan-24-oic-2,2,4,4-d4 acid. CAS Number: 99102-69-9. Synonyms: CDCA-d4. Molecular Formula: C24H36D4O4. Formula Weight: 396.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. SMILES: O[C@@H]1C([2H])([2H])C[C@@]2(C)[C@@](C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(O)=O)([H])C1([2H])[2H]. InChi Code: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1/i8D2,12D2. InChi Key: RUDATBOHQWOJDD-PSTGXAJBSA-N.
Keywords: CDCA-d4, 3alpha,7alpha-dihydroxy-5beta-cholan-24-oic-2,2,4,4-d4 acid
Supplier: Cayman Chemical
Supplier-Nr: 20848

Properties

Application: GC-MS, LC-MS, Internal standard, CDCA quantification
MW: 396.6 D
Formula: C24H36D4O4
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 99102-69-9| Matching products
KEGG ID : K08537 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319
P Phrases: P264, P280, P302+352, P305+351+338, P321, P332+313, P337+313, P362+364
Caution
Our products are for laboratory research use only: Not for administration to humans!
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