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Chenodeoxycholic acid-d4 (CDCA-d4) is intended for use as an internal standard for the... more
Product information "Chenodeoxycholic Acid-d4"
Chenodeoxycholic acid-d4 (CDCA-d4) is intended for use as an internal standard for the quantification of CDCA (Cay-10011286) by GC- or LC-MS. CDCA is a hydrophobic primary bile acid. It is formed from cholesterol in the liver via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. CDCA is a farnesoid X receptor (FXR) agonist that binds to FXRs in a TR-FRET assay (EC50 = 13 µM) and induces FXR transactivation in a reporter assay. It induces transcription of the gene encoding the Nrf2 target glutamate cysteine ligase (GCL) in primary hepatocytes and HepG2 cells when used at concentrations ranging from 25 to 100 µM.Formal Name: 3alpha,7alpha-dihydroxy-5beta-cholan-24-oic-2,2,4,4-d4 acid. CAS Number: 99102-69-9. Synonyms: CDCA-d4. Molecular Formula: C24H36D4O4. Formula Weight: 396.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. SMILES: O[C@@H]1C([2H])([2H])C[C@@]2(C)[C@@](C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(O)=O)([H])C1([2H])[2H]. InChi Code: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1/i8D2,12D2. InChi Key: RUDATBOHQWOJDD-PSTGXAJBSA-N.
Keywords: | CDCA-d4, 3alpha,7alpha-dihydroxy-5beta-cholan-24-oic-2,2,4,4-d4 acid |
Supplier: | Cayman Chemical |
Supplier-Nr: | 20848 |
Properties
Application: | GC-MS, LC-MS, Internal standard, CDCA quantification |
MW: | 396.6 D |
Formula: | C24H36D4O4 |
Purity: | >95% |
Format: | Crystalline Solid |
Database Information
CAS : | 99102-69-9| Matching products |
KEGG ID : | K08537 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H315, H319 |
P Phrases: | P264, P280, P302+352, P305+351+338, P321, P332+313, P337+313, P362+364 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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