Ch 55

Ch 55 is a synthetic analog of retinoic acid (Cay-11017) that binds to retinoic acid receptors with similar efficiency as retinoic acid (Kis in the nM range) yet does not display affinity for cellular retinoic acid-binding protein (Ki = 540 µM). Ch 55 has been shown to inhibit squamous cell differentiation of rabbit tracheal epithelial cells by inhibiting type I transglutaminase activity (EC50 = 0.02 nM) and increasing cholesterol sulfate levels (EC50 = 0.03 nM). In contrast, it has also been shown to induce differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC50s = 0.26 and 0.5 nM, respectively), as well as inhibit the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM).Formal Name: 4-[(1E)-3-[3,5-bis(1,1-dimethylethyl)phenyl]-3-oxo-1-propen-1-yl]-benzoic acid. CAS Number: 110368-33-7. Molecular Formula: C24H28O3. Formula Weight: 364.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml, Ethanol: 5 mg/ml. lambdamax: 308 nm. SMILES: CC(C)(C)C1=CC(C(C)(C)C)=CC(C(/C=C/C2=CC=C(C(O)=O)C=C2)=O)=C1. InChi Code: InChI=1S/C24H28O3/c1-23(2,3)19-13-18(14-20(15-19)24(4,5)6)21(25)12-9-16-7-10-17(11-8-16)22(26)27/h7-15H,1-6H3,(H,26,27)/b12-9+. InChi Key: FOUVTBKPJRMLPE-FMIVXFBMSA-N.