CGP 37157

CGP 37157 is a benzothiazepine that acts as a selective inhibitor of the mitochondrial sodium-calcium exchanger (IC50 = 0.36 µM in isolated mitochondria). It does not affect channels, exchangers, or ATPases on the cardiac sarcolemma or ATPases on sarcoplasmic reticulum. CGP 37157 is commonly used to study the role of mitochondrial-derived calcium in cytoplasmic calcium homeostasis. CGP 37157 inhibits sodium-dependent calcium efflux via the mitochondrial exchanger NCLX in a variety of cell types (IC50 = 5 µM).Formal Name: 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one. CAS Number: 75450-34-9. Molecular Formula: C15H11Cl2NOS. Formula Weight: 324.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Ethanol: 25 mM. SMILES: O=C1CSC(C2=CC=CC=C2Cl)C3=CC(Cl)=CC=C3N1. InChi Code: InChI=1S/C15H11Cl2NOS/c16-9-5-6-13-11(7-9)15(20-8-14(19)18-13)10-3-1-2-4-12(10)17/h1-7,15H,8H2,(H,18,19). InChi Key: KQEPIRKXSUIUTH-UHFFFAOYSA-N.