CGP 36742

CGP 36742 is an antagonist of GABAB receptors (IC50 = 36 µM). It is selective for GABAB over a panel of 11 receptors, including GABAA, at 1 mM. CGP 36742 (3 mg/kg) reduces paired-pulse inhibition of the late inhibitory postsynaptic potential (IPSP) in CA1 pyramidal neurons in rats. It increases latency to step-down in a passive avoidance test in mice in a dose-dependent manner. CGP 36742 (10 and 30 mg/kg) decreases immobility time in the forced swim test in mice.Formal Name: P-(3-aminopropyl)-P-butyl-phosphinic acid. CAS Number: 123690-78-8. Synonyms: 3-Aminopropyl-n-butylphosphinic Acid, SGS 742. Molecular Formula: C7H18NO2P. Formula Weight: 179.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: soluble. SMILES: O=P(CCCN)(CCCC)O. InChi Code: InChI=1S/C7H18NO2P/c1-2-3-6-11(9,10)7-4-5-8/h2-8H2,1H3,(H,9,10). InChi Key: ONNMDRQRSGKZCN-UHFFFAOYSA-N.