CGP 20712A

CGP 20712A is an antagonist of the beta1-adrenergic receptor (beta1-AR, IC50 = 0.7 nM). It is selective for beta1-ARs over beta2-ARs (IC50 = 6,700 nM). CGP 20712 A (0.1-1,000 µM) inhibits adenylyl cyclase activity induced by the beta1- and beta2-AR agonist isoproterenol (Cay-15592) in brown adipose tissue plasma membranes isolated from both lean and pre-obese rat pups.Formal Name: 2-hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]phenoxy]propyl]amino]ethoxy]-benzamide, monomethanesulfonate. CAS Number: 105737-62-0. Molecular Formula: C23H25F3N4O5 . CH3SO3H. Formula Weight: 590.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly Soluble: 0.1-1mg/ml, DMSO: Sparingly Soluble: 1-10 mg/ml, Methanol: Slightly Soluble: 0.1-1mg/ml. SMILES: O=C(C1=CC(OCCNCC(COC2=CC=C(C3=NC(C(F)(F)F)=CN3C)C=C2)O)=CC=C1O)N.O=S(O)(C)=O. InChi Code: InChI=1S/C23H25F3N4O5.CH4O3S/c1-30-12-20(23(24,25)26)29-22(30)14-2-4-16(5-3-14)35-13-15(31)11-28-8-9-34-17-6-7-19(32)18(10-17)21(27)33,1-5(2,3)4/h2-7,10,12,15,28,31-32H,8-9,11,13H2,1H3,(H2,27,33),1H3,(H,2,3,4). InChi Key: VFPOVCXWKBYDNF-UHFFFAOYSA-N.