cGAMP disodium

Description: cGAMP disodium is a cyclic dinucleotide (CDN) found in bacteria that acts as an endogenous second messenger affecting interferon production in response to cytoplasmic DNA. cGAMP disodium cascades signals from type I interferons and other immune mediators by activating interferon gene stimulator (STING). cGAMP disodium is a potent sublingual immune adjuvant that enables better immune function (serum anti-PA neutralization and airway secretions anti-PA SIgA response). Target: Others. Smiles: O[C@H]1[C@@H](O[C@@]2([H])[C@@]1([H])OP(O)(OC[C@]3([H])[C@@]([C@H]([C@H](N4C5=NC=NC(N)=C5N=C4)O3)O)([H])OP(O)(OC2)=O)=O)N6C7=C(C(N=C(N7)N)=O)N=C6.[Na].[Na]. References: Jiaxi Wu, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15,339(6121):826-30.