Cevimeline (hydrochloride)

Cevimeline is a muscarinic receptor agonist (EC50s = 23, 48, and 63 nM for M1, M3, and M5, respectively, and >1 µM for M2 and M4). It stimulates secretion by salivary glands and is useful in ameliorating xerostomia (dry mouth).Formal Name: (2'R,3R)-rel-2'-methyl-spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane], monohydrochloride. CAS Number: 107220-28-0. Synonyms: AF 102B, SNI 2011, SNK 508. Molecular Formula: C10H17NOS . HCl. Formula Weight: 235.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 5 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: C[C@@H](SC1)O[C@@]21CN3CCC2CC3.Cl. InChi Code: InChI=1S/C10H17NOS.ClH/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11,/h8-9H,2-7H2,1H3,1H/t8-,10-,/m1./s1. InChi Key: SURWTGAXEIEOGY-GHXDPTCOSA-N.