CEP-37440

CEP-37440 is a dual inhibitor of focal adhesion kinase 1 (FAK1, IC50s = 2.0 and 80 nM for in vitro enzyme and cellular inhibition, respectively) and anaplastic lymphoma kinase (ALK, IC50s = 3.1 and 22 nM for in vitro enzyme and cellular inhibition, respectively). It blocks the proliferation of inflammatory and triple-negative breast cancer cell lines but not normal breast epithelial cells. CEP-37440 reduces the growth and metastasis of breast cancer xenografts in mice when given by oral gavage.Formal Name: 2-[[5-chloro-2-[[(6S)-6,7,8,9-tetrahydro-6-[4-(2-hydroxyethyl)-1-piperazinyl]-1-methoxy-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-N-methyl-benzamide. CAS Number: 1391712-60-9. Molecular Formula: C30H38ClN7O3. Formula Weight: 580.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 12 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 279, 333 nm. SMILES: O=C(NC)C1=CC=CC=C1NC2=NC(NC3=C(OC)C(CCC[C@H](N4CCN(CCO)CC4)C5)=C5C=C3)=NC=C2Cl. InChi Code: InChI=1S/C30H38ClN7O3/c1-32-29(40)23-7-3-4-9-25(23)34-28-24(31)19-33-30(36-28)35-26-11-10-20-18-21(6-5-8-22(20)27(26)41-2)38-14-12-37(13-15-38)16-17-39/h3-4,7,9-11,19,21,39H,5-6,8,12-18H2,1-2H3,(H,32,40)(H2,33,34,35,36)/t21-/m0/s1. InChi Key: BCSHRERPHLTPEE-NRFANRHFSA-N.