CeMMEC13

CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 µM). It does not bind to bromodomains of BRD4, BRD9, or CREBBP. CeMMEC13 synergizes with (+)-JQ1 (Cay-11187) to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells.Formal Name: N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-1-methyl-2-oxo-4-quinolinecarboxamide. CAS Number: 1790895-25-8. Molecular Formula: C19H16N2O4. Formula Weight: 336.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 211, 337 nm. SMILES: O=C(C1=CC(N(C)C2=C1C=CC=C2)=O)NC3=CC4=C(C=C3)OCCO4. InChi Code: InChI=1S/C19H16N2O4/c1-21-15-5-3-2-4-13(15)14(11-18(21)22)19(23)20-12-6-7-16-17(10-12)25-9-8-24-16/h2-7,10-11H,8-9H2,1H3,(H,20,23). InChi Key: NXKBPGZQDHACPZ-UHFFFAOYSA-N.