CeMMEC1

CeMMEC1 is an N-methylisoquinolinone that inhibits the second bromodomain of TAF1 (Kd = 1.8 µM, IC50 = 0.9 µM). It does not bind to either the first or second bromodomain of BRD4. This compound synergizes with (+)-JQ1 (Cay-11187) to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells.Formal Name: N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-2-methyl-1-oxo-4-isoquinolinecarboxamide. CAS Number: 440662-09-9. Molecular Formula: C19H16N2O4. Formula Weight: 336.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 212, 258, 296 nm. SMILES: O=C(C1=CN(C)C(C2=C1C=CC=C2)=O)NC3=CC4=C(C=C3)OCCO4. InChi Code: InChI=1S/C19H16N2O4/c1-21-11-15(13-4-2-3-5-14(13)19(21)23)18(22)20-12-6-7-16-17(10-12)25-9-8-24-16/h2-7,10-11H,8-9H2,1H3,(H,20,22). InChi Key: PEOQAZBGLOADFJ-UHFFFAOYSA-N.