Celecoxib

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC50 = 0.05 µM). It is selective for COX-2 over COX-1 (IC50 = 22.9 µM). Celecoxib induces apoptosis in BJAB and Jurkat cancer cells in a concentration-dependent manner. It reduces blood glucose levels in a rat model of diabetes induced by streptozotocin (STZ, Cay-13104). Celecoxib reduces the latency to escape and the path length in the Morris water maze, as well as increases BDNF and tropomyosin-related kinase B (TrkB) protein levels in the hippocampus, in the same model. It inhibits the production of IL-1beta and TNF-alpha and reduces synovial fluid expression of the gene encoding matrix metalloproteinase-3 (MMP-3) in a rabbit model of osteoarthritis when administered intra-articularly. Celecoxib (100 mg/kg per day) increases serum levels of lactate dehydrogenase (LDH), troponin-T, TNF-alpha, and creatine kinase-MB (CK-MB), markers of cardiotoxicity, in rats. Formulations containing celecoxib have been used in the treatment of osteoarthritis, and rheumatoid arthritis, and as an analgesic.Formal Name: 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide. CAS Number: 169590-42-5. Synonyms: SC-58635, YM-177. Molecular Formula: C17H14F3N3O2S. Formula Weight: 381.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 15 mg/ml, Ethanol: 25 mg/ml, Ethanol:PBS (pH 7.2) (1:4): 0.1 mg/ml. lambdamax: 204, 254 nm. SMILES: NS(C1=CC=C(N2C(C3=CC=C(C)C=C3)=CC(C(F)(F)F)=N2)C=C1)(=O)=O. InChi Code: InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25). InChi Key: RZEKVGVHFLEQIL-UHFFFAOYSA-N.