Celastrol

A variety of natural products from plant sources, particularly flavonoids, have long been observed to have antioxidant activity with potential benefits for human health. Antioxidant triterpenes are less common. Celastrol is a triterpenoid antioxidant compound isolated from Chinese thunder god vine (T. wilfordii). In an isolated rat liver assay of lipid peroxidation, celastrol had an IC50 value of 7 µM, equivalent to about 15 times the antioxidant potency of alpha-tocopherol.Formal Name: 3-hydroxy-9beta,13alpha-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid. CAS Number: 34157-83-0. Molecular Formula: C29H38O4. Formula Weight: 450.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Ethanol: 10 mg/ml, DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:10): 1 mg/ml, DMSO: 10 mg/ml. lambdamax: 253, 424 nm. SMILES: O=C1C=C2C(=CC=C3[C@@]2(C)CCC2(C)[C@@H]4C[C@@](C)(CC[C@]4(C)CC[C@]32C)C(=O)O)C(=C1O)C. InChi Code: InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26?,27+,28-,29+/m1/s1. InChi Key: KQJSQWZMSAGSHN-KUDKLYNCSA-N.