Cefsulodin (sodium salt hydrate)

Cefsulodin is a cephalosporin antibiotic. It is active against 45 isolates of P. aeruginosa (MIC90 = 3.1 µg/ml) and acts synergistically against P. aeruginosa isolates when combined with gentamicin, tobramycin (Cay-14596), amikacin (Cay-15405), or mezlocillin (Cay-30691). Cefsulodin is also active against isolates of S. aureus, S. epidermidis, S. pneumoniae, and S. pyogenes (MIC90s = 8, 8, 12, and 12 µg/ml, respectively). It binds to P. aeruginosa penicillin-binding protein 1a (PBP1a), PBP1b, and PBP3 but not PBP2, PBP4, or PBP5. It increases survival in mice infected with various P. aeruginosa strains (ED50s = 1.93-137 mg/kg for all). Formulations containing cefsulodin have been used in the treatment of P. aeruginosa infections.Formal Name: 4-(aminocarbonyl)-1-[[(6R,7R)-2-carboxy-8-oxo-7-[[(2R)-2-phenyl-2-sulfoacetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-pyridinium inner salt, monosodium salt, hydrate. CAS Number: 1426397-23-0. Molecular Formula: C22H19N4O8S2 . Na [XH2O]. Formula Weight: 531.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.1 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 265, 352 nm. SMILES: O=C(N[C@@H]1C(N2[C@]1([H])SCC(C[N+]3=CC=C(C(N)=O)C=C3)=C2C([O-])=O)=O)[C@H](S([O-])(=O)=O)C4=CC=CC=C4.[Na+].O. InChi Code: InChI=1S/C22H20N4O8S2.Na.H2O/c23-18(27)13-6-8-25(9-7-13)10-14-11-35-21-15(20(29)26(21)16(14)22(30)31)24-19(28)17(36(32,33)34)12-4-2-1-3-5-12,,/h1-9,15,17,21H,10-11H2,(H4-,23,24,27,28,30,31,32,33,34),,1H2/q,+1,/p-1/t15-,17-,21-,,/m1../s1. InChi Key: XTRRFIYXAPRYES-NLFZDHTNSA-M.