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Product information "Cefepime (hydrochloride hydrate)"
Cefepime is a broad-spectrum cephalosporin antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria. It inhibits the growth of some clinical isolates of Corynebacterium, Streptococcus, and Staphylococcus (MIC90s = 0.03-8 µg/ml), but does not inhibit the growth of methicillin-resistant S. aureus (MRSA) or S. haemolyticus (MIC50s = >128 µg/ml). Cefepime inhibits the growth of some Citrobacter, Enterobacter, Klebsiella, Salmonella, Serratia, Shigella, and enteric bacilli species in addition to P. mirabilis and E. coli clinical isolates (MIC90s = =0.12-2 µg/ml). It also inhibits the growth of E. coli and Klebsiella strains that produce extended-spectrum beta-lactamase (ESBL, MIC90s = 4 and 8 µg/mL, respectively) and of indole-positive Proteae (MIC90 = 0.25 µg/ml). Cefepime inhibits the growth of pneumococci strains (MICs = 0.5-2 mg/l) in vitro and in vivo in a mouse model of peritonitis (ED50s = 0.6-1.14 mg/kg). Formulations containing cefepime have been used in the treatment of a variety of bacterial infections.Formal Name: 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-pyrrolidinium, monochloride, monohydrochloride, monohydrate. CAS Number: 123171-59-5. Molecular Formula: C19H25N6O5S2 . Cl [HCl] [H2O]. Formula Weight: 571.5. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.1 mg/ml, DMSO: 0.2 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 238, 264 nm. SMILES: O=C(O)C1=C(C[N+]2(C)CCCC2)CS[C@@]([C@@H]3NC(/C(C4=CSC(N)=N4)=N\OC)=O)([H])N1C3=O.[Cl-].Cl.O. InChi Code: InChI=1S/C19H24N6O5S2.2ClH.H2O/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11,,,/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29),2*1H,1H2/b23-12-,,,/t13-,17-,,,/m1.../s1. InChi Key: LRAJHPGSGBRUJN-OMIVUECESA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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