(+)-Cedrol

(+)-Cedrol is a sesquiterpene alcohol that has been used in Cannabis testing and has diverse biological activities. It inhibits the growth of L. sulphureus, G. trabeum, L. betulina, and T. versicolor wood decay fungi when used at a concentration of 100 µg/ml. (+)-Cedrol inhibits the cytochrome P450 (CYP) isoforms CYP2B6 and CYP3A4 (Kis = 0.9 and 3.4 µM, respectively). In vivo, (+)-cedrol (200 mg/kg) prevents hair follicle dystrophy and reduces hair loss in a mouse model of alopecia induced by cyclophosphamide (Cay-13849). (+)-Cedrol-loaded nanostructured lipid particles reduce peritoneal mast cell degranulation, a component of the type I anaphylactic response, induced by compound 48/80 (Cay-22173) in mice.Formal Name: (3R,3aS,6R,7R,8aS)-octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-6-ol. CAS Number: 77-53-2. Synonyms: alpha-Cedrol. Molecular Formula: C15H26O. Formula Weight: 222.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly Soluble, Methanol: Heated. SMILES: CC([C@]1([H])[C@](C)(O)CC2)(C)[C@@]3([H])[C@@]2(C1)[C@H](C)CC3. InChi Code: InChI=1S/C15H26O/c1-10-5-6-11-13(2,3)12-9-15(10,11)8-7-14(12,4)16/h10-12,16H,5-9H2,1-4H3/t10-,11+,12-,14-,15+/m1/s1. InChi Key: SVURIXNDRWRAFU-OGMFBOKVSA-N.