CDPPB

CDPPB is a positive allosteric modulator (PAM) of metabotropic glutamate receptor 5 (mGluR5). It potentiates glutamate-induced increases in intracellular calcium in CHO cells expressing mGluR5 (EC50s = 10 and 20 nM for the human and rat receptor, respectively). CDPPB (30 mg/kg, s.c.) inhibits amphetamine-induced disruptions in prepulse inhibition (PPI) of the acoustic startle response in rats.Formal Name: 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)-benzamide. CAS Number: 781652-57-1. Molecular Formula: C23H16N4O. Formula Weight: 364.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 264 nm. SMILES: O=C(C1=CC=CC(C#N)=C1)NC2=CC(C3=CC=CC=C3)=NN2C4=CC=CC=C4O=C(C1=CC=CC(C#N)=C1)NC2=CC(C3=CC=CC=C3)=NN2C4=CC=CC=C4. InChi Code: InChI=1S/C23H16N4O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20/h1-15H,(H,25,28). InChi Key: BKUIZWILNWHFHD-UHFFFAOYSA-N.