CD2665

CD2665 is a selective retinoic acid receptor (RAR)beta and RARgamma antagonist (Kds = 110, 306, and > 2,250 nM for RARgamma, RARbeta, and RARalpha, respectively, with no binding at RXRalpha). At 10-7 M, it has been used to abrogate retinoic acid (Cay-11017)-induced antiproliferative and antidifferentiative effects on sebocyte growth. This compound has been used in animal and in vitro cell models to explore the role of retinoid signaling in a number of biological processes including memory formation and tumor proliferation.Formal Name: 4-[6-[(2-methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl]-benzoic acid. CAS Number: 170355-78-9. Molecular Formula: C31H34O5. Formula Weight: 486.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 25 mg/ml. lambdamax: 229, 273, 313 nm. SMILES: OC(C1=CC=C(C2=CC(C=C(C34C[C@H]5C[C@H](C[C@@H](C4)C5)C3)C(OCOCCOC)=C6)=C6C=C2)C=C1)=O. InChi Code: InChI=1S/C31H34O5/c1-34-8-9-35-19-36-29-15-26-7-6-25(23-2-4-24(5-3-23)30(32)33)13-27(26)14-28(29)31-16-20-10-21(17-31)12-22(11-20)18-31/h2-7,13-15,20-22H,8-12,16-19H2,1H3,(H,32,33)/t20-,21+,22-,31?. InChi Key: JBALRFFXKQPVLT-BUPRXJOYSA-N.