CCT241161

Description: CCT241161 is an orally active pan-RAF inhibitor, with IC50 values of 3, 6, 10, 15, and 30 nM for LCK, CRAF, SRC, V600E-BRAF, and BRAF, respectively. It exhibits significant activity against BRAF and NRAS mutant melanomas and demonstrates anticancer cell proliferative effects [1]. Target: Raf. Smiles: N(C(NC1=C(SC)C=C(OC2=C3C(=NC=C2)NC(=O)C=N3)C=C1)=O)C=4N(N=C(C(C)(C)C)C4)C5=CC=CC=C5. References: Girotti MR, et al. Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma. Cancer Cell. 2015 Jan 12,27(1):85-96.