CB-7921220

CB-7921220 is an inhibitor of the adenylyl cyclase (AC) isoforms AC1 and AC6. It is selective, reducing AC1 and AC6 activity by 60% while having no effect on AC2 and AC5 in Sf9 membranes stimulated by forskolin (Cay-11018) when used at a concentration of 100 µM.Formal Name: 6-[2-(4-aminophenyl)ethenyl]-2-pyridinecarboxylic acid. CAS Number: 115453-99-1. Molecular Formula: C14H12N2O2. Formula Weight: 240.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, PBS (pH 7.2): 0.3 mg/ml. lambdamax: 353 nm. SMILES: NC(C=C1)=CC=C1/C=C/C2=NC(C(O)=O)=CC=C2. InChi Code: InChI=1S/C14H12N2O2/c15-11-7-4-10(5-8-11)6-9-12-2-1-3-13(16-12)14(17)18/h1-9H,15H2,(H,17,18)/b9-6+. InChi Key: QASPDWZDKLUOPO-RMKNXTFCSA-N.