CAY10762

Description: CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL, IC50= 34.1 nM) that reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells at a concentration of 1 µM and increases levels of 2-arachidonoyl glycerol in mouse brain at 10 mg/kg. Target: Others. Smiles: O=C1C=2C(SN1CCC3=CC=CC=C3)=CC=CC2. References: Castelli, R., Scalvini, L., Vacondio, F., et al.Benzisothiazolinone derivatives as potent allosteric monoacylglycerol lipase inhibitors that functionally mimic sulfenylation of regulatory cysteinesJ. Med. Chem.63(3)1261-1280(2020)