CAY10760

CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50 = 19 µM in a cell-free competitive ELISA). It decreases homologous recombination by 54% in wild-type BRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 µM. CAY10760 (20 µM) decreases proliferation of BxPC-3, as well as mutant BRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib (Cay-10621).Formal Name: 6-chloro-3-[4,5-dihydro-5-(4-methoxyphenyl)-1-(1-oxopropyl)-1H-pyrazol-3-yl]-4-phenyl-2(1H)-quinolinone. CAS Number: 391889-85-3. Molecular Formula: C28H24ClN3O3. Formula Weight: 486.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 11mg/mL, DMF:PBS (pH 7.2) (1:2): 0.3mg/mL, DMSO: 10mg/mL. lambdamax: 234 nm. SMILES: O=C1NC2=C(C=C(Cl)C=C2)C(C3=CC=CC=C3)=C1C4=NN(C(CC)=O)C(C5=CC=C(OC)C=C5)C4. InChi Code: InChI=1S/C28H24ClN3O3/c1-3-25(33)32-24(17-9-12-20(35-2)13-10-17)16-23(31-32)27-26(18-7-5-4-6-8-18)21-15-19(29)11-14-22(21)30-28(27)34/h4-15,24H,3,16H2,1-2H3,(H,30,34). InChi Key: LAVOKBSCOSIGER-UHFFFAOYSA-N.