CAY10721

Description: CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 µM). Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph node involvement, while SIRT3 down-regulation inhibits the growth of OSCC cells and sensitizes them to radiation and chemotherapy. Target: Others. Smiles: OC1=CC(NC(=O)CSC2=NC=NC3=C2OC2=C3C=CC=C2)=CC=C1