CAY10721

CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 µM). Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph node involvement, while SIRT3 down-regulation inhibits the growth of OSCC cells and sensitizes them to radiation and chemotherapy.Formal Name: 2-(benzofuro[3,2-d]pyrimidin-4-ylthio)-N-(3-hydroxyphenyl)-acetamide. CAS Number: 848688-62-0. Molecular Formula: C18H13N3O3S. Formula Weight: 351.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml. lambdamax: 211, 237, 293 nm. SMILES: O=C(NC1=CC(O)=CC=C1)CSC2=NC=NC3=C2OC4=C3C=CC=C4. InChi Code: InChI=1S/C18H13N3O3S/c22-12-5-3-4-11(8-12)21-15(23)9-25-18-17-16(19-10-20-18)13-6-1-2-7-14(13)24-17/h1-8,10,22H,9H2,(H,21,23). InChi Key: ZXXJUSSVHKICFE-UHFFFAOYSA-N.