CAY10649

5-Lipoxygenase (5-LO) catalyzes the biosynthesis of leukotrienes, which are involved in a variety of inflammatory responses, including neutrophil chemotaxis, vascular permeability, and smooth muscle contraction. CAY10649 is a thiazolinone compound that demonstrates direct inhibition of 5-lipoxygenase (5-LO) product formation in intact polymorphonuclear leukocytes (PMNL) (IC50 = 0.28 µM) and a soluble fraction of a S100 PMNL cell lysate (IC50 = 0.09 µM) after stimulation with calcium and arachidonic acid.Formal Name: (Z)-2-(4-chlorophenyl)-5-(4-methoxybenzylidene)thiazol-4(5H)-one. CAS Number: 1272519-89-7. Molecular Formula: C17H12ClNO2S. Formula Weight: 329.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 0.5 mg/ml. lambdamax: 297, 428 nm. SMILES: COC1=CC=C(/C=C2C(N=C(C3=CC=C(Cl)C=C3)S/2)=O)C=C1. InChi Code: InChI=1S/C17H12ClNO2S/c1-21-14-8-2-11(3-9-14)10-15-16(20)19-17(22-15)12-4-6-13(18)7-5-12/h2-10H,1H3/b15-10-. InChi Key: BYPSEBXZQCBFIP-GDNBJRDFSA-N.