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CAY10621 is an inhibitor of sphingosine kinase 1 (SPHK1, IC50 = 3.3 µM). It is selective for SPHK1 over SPHK2 at 10 µM and PKC at concentrations less than 100 µM. CAY10621 inhibits SPHK1 activity by 70% in U937 cells when used at a concentration of 5 µM.Formal Name: (4S)-2,2-dimethyl-4-(1-oxo-2-hexadecyn-1-yl)-3-oxazolidinecarboxylic acid, 1,1-dimethylethyl ester. CAS Number: 120005-55-2. Synonyms: SKI 5C, SPHK1 Inhibitor 5C. Molecular Formula: C26H45NO4. Formula Weight: 435.6. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 3 mg/ml, DMSO: 2 mg/ml, Ethanol: 2.5 mg/ml. lambdamax: 224 nm. SMILES: CCCCCCCCCCCCCCCC(=O)[C@@H]1COC(C)(C)N1C(=O)OC(C)(C)C. InChi Code: InChI=1S/C26H45NO4/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-23(28)22-21-30-26(5,6)27(22)24(29)31-25(2,3)4/h22H,7-18,21H2,1-6H3/t22-/m1/s1. InChi Key: YGBSGZPIDCXNEH-JOCHJYFZSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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