CAY10568

Most local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons. Selective analgesia through TRPV1-mediated entry of a cationic lidocaine derivative, QX314, was recently reported. CAY10568 is a physically smaller, less hydrophobic version of QX314 designed to be even more permeable to TRPV1 ion channel when activated by agonists such as capsaicin and N-oleoyl dopamine. CAY10568 when given in combination with suitable TRPV1 agonists should produce selective blockade of the pain response while leaving motor, touch, and proprioception intact.Formal Name: trimethyl[(phenylcarbamoyl)methyl]-ammonium iodide. CAS Number: 22913-17-3. Synonyms: Santinamide. Molecular Formula: C11H17N2O . I. Formula Weight: 320.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 3 mg/ml, PBS (pH 7.2): 0.5 mg/ml. SMILES: [I-].O=C(Nc1ccccc1)C[N+](C)(C)C. InChi Code: InChI=1S/C11H16N2O.HI/c1-13(2,3)9-11(14)12-10-7-5-4-6-8-10,/h4-8H,9H2,1-3H3,1H. InChi Key: CCPHDQUNJSJNQK-UHFFFAOYSA-N.