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Description: Acyl-Coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10486 inhibits human ACAT-1 and ACAT-2 equally with an IC50 value of approximately 60 µM. It also inhibits copper-mediated oxidation of low density lipoproteins by about 28% at a concentration of 3 µM. Target: Others. Smiles: [C@@H](CC1=CC=CC=C1)(NC(C=CC2=CC=C(O)C=C2)=O)C(OC)=O
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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