CAY10486

Acyl-Coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10486 inhibits human ACAT-1 and ACAT-2 equally with an IC50 value of approximately 60 µM. It also inhibits copper-mediated oxidation of low density lipoproteins by about 28% at a concentration of 3 µM.Formal Name: N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester. CAS Number: 615264-52-3. Synonyms: 4-hydroxy Cinnamic Acid (L-Phenylalanine methyl ester) amide. Molecular Formula: C19H19NO4. Formula Weight: 325.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2)(1:5): 0.5 mg/ml, Ethanol: 20 mg/ml. lambdamax: 210, 226, 311 nm. SMILES: O=C(N[C@@H](CC1=CC=CC=C1)C(OC)=O)/C=C/C2=CC=C(O)C=C2. InChi Code: InChI=1S/C19H19NO4/c1-24-19(23)17(13-15-5-3-2-4-6-15)20-18(22)12-9-14-7-10-16(21)11-8-14/h2-12,17,21H,13H2,1H3,(H,20,22)/b12-9+. InChi Key: ATJBWQGWPYQIAR-FMIVXFBMSA-N.