Catharanthine (tartrate)

Catharanthine is an indole alkaloid that has been found in C. roseus and has diverse biological activities. It is a precursor in the biosynthesis of the antimitotic agents vinblastine (Cay-11762) and vincristine (Cay-11764). Catharanthine (320 µM) inhibits microtubule assembly and the proliferation of HCT116 colon cancer cells (IC50 = 60 µg/ml). It induces the release of amylase from mouse pancreas preparations when used at a concentration of 100 µM. Catharanthine (0.5-20 mg/kg) decreases blood pressure and heart rate in anesthetized normotensive rats.Formal Name: (2alpha,5beta,6alpha)-3,4-didehydro-ibogamine-18beta-carboxylic acid, methyl ester, 2R,3R-dihydroxybutanedioate (2:1). CAS Number: 4168-17-6. Synonyms: (+)-3,4-Didehydrocoronaridine. Molecular Formula: C21H24N2O2 . 1/2C4H6O6. Formula Weight: 486.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml. lambdamax: 224, 283 nm. SMILES: CCC1=C[C@H]2C[C@]([C@]1([H])[N@@](C2)CC3)(C(OC)=O)C4=C3C5=C(N4)C=CC=C5.OC([C@@H]([C@@H](O)C(O)=O)O)=O.CCC6=C[C@H]7C[C@]([C@]6([H])[N@@](C7)CC8)(C(OC)=O)C9=C8C%10=C(N9)C=CC=C%10. InChi Code: InChI=1S/2C21H24N2O2.C4H6O6/c2*1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18,5-1(3(7)8)2(6)4(9)10/h2*4-7,10,13,19,22H,3,8-9,11-12H2,1-2H3,1-2,5-6H,(H,7,8)(H,9,10)/t2*13-,19+,21-,1-,2-/m001/s1. InChi Key: OXIDCVCPXUNSCI-DWGLLIDUSA-N. Origin: Plant/Vinca rosea.