Carebastine-d5

Carebastine-d5 is intended for use as an internal standard for the quantification of carebastine (Cay-23076) by GC- or LC-MS. Carebastine is an active metabolite of ebastine (Cay-15372) and a histamine H1 receptor antagonist (Ki = 75.86 nM). It inhibits histamine-induced contraction of isolated guinea pig trachea (IC50 = 120 nM). It also inhibits histamine release from isolated rat peritoneal mast cells and human basophils when used at concentrations ranging from 30 to 100 µM. Carebastine decreases production of chemokine (C-C motif) ligand 5 (CCL5) and CCL2 in human nasal epithelial cells isolated from patients with nasal allergies.Formal Name: 4-[4-[4-(phenyl-d5)-phenylmethoxy)-1-piperidinyl]-1-oxobutyl]-alpha,alpha-dimethyl benzeneacetic acid. CAS Number: 1189661-02-6. Molecular Formula: C32H32D5NO4. Formula Weight: 504.7. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: Chloroform: slightly soluble, Ethyl Acetate: slightly soluble. SMILES: O=C(C1=CC=C(C(C)(C)C(O)=O)C=C1)CCCN(CC2)CCC2OC(C3=CC=CC=C3)C4=C([2H])C([2H])=C([2H])C([2H])=C4[2H]. InChi Code: InChI=1S/C32H37NO4/c1-32(2,31(35)36)27-17-15-24(16-18-27)29(34)14-9-21-33-22-19-28(20-23-33)37-30(25-10-5-3-6-11-25)26-12-7-4-8-13-26/h3-8,10-13,15-18,28,30H,9,14,19-23H2,1-2H3,(H,35,36)/i3D,5D,6D,10D,11D. InChi Key: XGHOVGYJHWQGCC-KILXEUBNSA-N.