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Carboxyamidotriazole is an orally bioavailable, non-selective calcium channel blocker. It blocks... more
Product information "Carboxyamidotriazole"
Carboxyamidotriazole is an orally bioavailable, non-selective calcium channel blocker. It blocks L- and T-type calcium channels in GH3 rat pituitary cancer cells (IC50s = 0.5 and 1.5 µg/ml, respectively). It also inhibits calcium influx stimulated by the acetylcholine receptor agonist carbachol (carbamoylcholine, Cay-14486) and the calcium ionophore A23187 (Cay-11016, Cay-22030) in CHO cells expressing human recombinant muscarinic M5 receptors (IC50s = 935 and 359 nM, respectively). Carboxyamidotriazole inhibits the growth of T. gondii in non-cancerous human fibroblasts and HeLa human cervical cancer cells (IC50 = 0.06 µg/ml for both). It inhibits the growth of FaDu and EVSCC17M human squamous cell carcinoma cells (IC50s = 13 and 15 µM, respectively) and of human umbilical vein endothelial cells (HUVECs, IC50 = 1 µM) in vitro. Carboxyamidotriazole (20 µM) also inhibits angiogenesis in a chicken chorioallantoic membrane assay in vivo.Formal Name: 5-amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide. CAS Number: 99519-84-3. Synonyms: CAI, L-651,582, NSC 609974. Molecular Formula: C17H12Cl3N5O2. Formula Weight: 424.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Methanol: slightly, heated. SMILES: ClC1=CC=C(C(C2=C(Cl)C=C(CN3N=NC(C(N)=O)=C3N)C=C2Cl)=O)C=C1. InChi Code: InChI=1S/C17H12Cl3N5O2/c18-10-3-1-9(2-4-10)15(26)13-11(19)5-8(6-12(13)20)7-25-16(21)14(17(22)27)23-24-25/h1-6H,7,21H2,(H2,22,27). InChi Key: WNRZHQBJSXRYJK-UHFFFAOYSA-N.
Keywords: | CAI, L-651,582, NSC 609974, 5-amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide |
Supplier: | Cayman Chemical |
Supplier-Nr: | 28732 |
Properties
Application: | Non-selective calcium channel blocker |
MW: | 424.7 D |
Formula: | C17H12Cl3N5O2 |
Purity: | >98% |
Format: | Solid |
Database Information
CAS : | 99519-84-3| Matching products |
KEGG ID : | K04857 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
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H Phrases: | H301 |
P Phrases: | P264, P270, P301+310, P321, P330, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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