Carbetapentane (citrate)

Carbetapentane is a sigma-1 (sigma1) receptor agonist (Ki = 10.4 nM). In vivo, carbetapentane (1-5 mg/kg) inhibits citric acid-induced cough in guinea pigs. Carbetapentane (12.5 and 25 mg/kg, i.p.) reduces the number of seizures, mortality, and hippocampal neuronal cell death in a rat model of kainate-induced seizures.Formal Name: 1-phenyl-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester, 2-hydroxy-1,2,3-propanetricarboxylate. CAS Number: 23142-01-0. Synonyms: Pentoxyverine citrate. Molecular Formula: C20H31NO3 . C6H8O7. Formula Weight: 525.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/mL, DMSO: 5 mg/mL, Ethanol: .3 mg/mL, PBS (pH 7.2): 5 mg/mL. SMILES: O=C(OCCOCCN(CC)CC)C1(C2=CC=CC=C2)CCCC1.OC(CC(O)=O)(C(O)=O)CC(O)=O. InChi Code: InChI=1S/C20H31NO3.C6H8O7/c1-3-21(4-2)14-15-23-16-17-24-19(22)20(12-8-9-13-20)18-10-6-5-7-11-18,7-3(8)1-6(13,5(11)12)2-4(9)10/h5-7,10-11H,3-4,8-9,12-17H2,1-2H3,13H,1-2H2,(H,7,8)(H,9,10)(H,11,12). InChi Key: AKJDEXBCRLOVTH-UHFFFAOYSA-N.