Carbamazepine 10,11-epoxide

Carbamazepine 10,11-epoxide is an active metabolite of the anticonvulsant carbamazepine. It is formed from carbamazepine by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C8 in microsomes prepared from HepG2 cells expressing CYP3A4 or CYP2C8, respectively. Carbamazepine 10,11-epoxide has anticonvulsant activity against maximal electroshock-induced seizures in mice. It has been found in wastewater effluent.Formal Name: 1a,10b-dihydro-6H-dibenz[b,f]oxireno[d]azepine-6-carboxamide. CAS Number: 36507-30-9. Synonyms: CBZ-E, CBZ 10,11-epoxide. Molecular Formula: C15H12N2O2. Formula Weight: 252.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml, DMSO: 1 mg/ml. lambdamax: 211 nm. SMILES: O=C(N1C2=C(C3OC3C4=C1C=CC=C4)C=CC=C2)N. InChi Code: InChI=1S/C15H12N2O2/c16-15(18)17-11-7-3-1-5-9(11)13-14(19-13)10-6-2-4-8-12(10)17/h1-8,13-14H,(H2,16,18). InChi Key: ZRWWEEVEIOGMMT-UHFFFAOYSA-N.