Candesartan

Candesartan is an antagonist of the angiotensin II type 1 (AT1) receptor (Kis = 0.17, 0.12, and 0.12 nM for recombinant human AT1, rat AT1A, and rat AT1B receptors, respectively) and an active metabolite of the prodrug candesartan cilexitil (Cay-10489). It is selective for AT1 over AT2 receptors (Ki = 26,500 nM for the recombinant human AT2 receptor). It inhibits angiotensin II-induced contraction of isolated rabbit aortic strips and increases in blood pressure in rats following intravenous administration (ID50 = 0.033 mg/kg). Formulations containing candesartan have been used in the treatment of hypertension and heart failure.Formal Name: 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid. CAS Number: 139481-59-7. Synonyms: Candesartan M1, CV-11974. Molecular Formula: C24H20N6O3. Formula Weight: 440.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml, DMSO: 15 mg/ml. SMILES: O=C(C1=CC=CC2=C1N(CC3=CC=C(C4=C(C5=NN=NN5)C=CC=C4)C=C3)C(OCC)=N2)O. InChi Code: InChI=1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29). InChi Key: HTQMVQVXFRQIKW-UHFFFAOYSA-N.