Calmidazolium (chloride)

Calmidazolium (chloride) is an inhibitor of calmodulin (CaM), inhibiting CaM-dependent phosphodiesterase and CaM-induced activation of erythrocyte calcium-transporting ATPase (IC50 = 0.15 and 0.35 µM, respectively). Calmidazolium also inhibits an array of calcium-transporting ATPases, including those from heart and skeletal muscle (IC50 = 2.1 and 2.9 µM, respectively). It also induces the influx of extracellular calcium through store-operated calcium channels (EC50 = 3 µM).Formal Name: 3-[bis(4-chlorophenyl)methyl]-1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazolium, monochloride. CAS Number: 57265-65-3. Synonyms: R 24571. Molecular Formula: C31H23Cl6N2O . Cl. Formula Weight: 687.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Ethanol: 100 mM. SMILES: ClC1=CC=C(C(N2C=[N+](CC(OCC3=CC=C(Cl)C=C3Cl)C4=CC=C(Cl)C=C4Cl)C=C2)C5=CC=C(Cl)C=C5)C=C1.[Cl-]. InChi Code: InChI=1S/C31H23Cl6N2O.ClH/c32-23-6-1-20(2-7-23)31(21-3-8-24(33)9-4-21)39-14-13-38(19-39)17-30(27-12-11-26(35)16-29(27)37)40-18-22-5-10-25(34)15-28(22)36,/h1-16,19,30-31H,17-18H2,1H/q+1,/p-1. InChi Key: YGEIMSMISRCBFF-UHFFFAOYSA-M.