Calcium D-Glucarate (hydrate)

Calcium D-glucarate is the calcium salt form of D-glucaric acid. D-Glucaric acid is an end product of D-glucuronic acid metabolism in mammals that has also been found in fruits and vegetables and has anticancer activity. It is produced by the oxidation of D-glucuronic acid and is a precursor in the biosynthesis of the beta-glucuronidase inhibitor D-glucaro-1,4-lactone (D-saccharic acid 1,4-lactone, Cay-18896) in vivo. Dietary administration of calcium D-glucarate (10% w/w) reduces tumor growth in a rat model of mammary tumorigenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA). Urinary D-glucaric acid levels have been used as a marker for xenobiotic-induced phase II metabolism in patients with rheumatoid arthritis or individuals exposed to environmental toxicants.Formal Name: D-glucaric acid calcium salt, monohydrate. CAS Number: 5793-89-5. Synonyms: Calcium D-Saccharate, D-Glucaric Acid Calcium Salt, D-Saccharic Acid Calcium Salt. Molecular Formula: C6H8O8 . Ca [4H2O]. Formula Weight: 320.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Methanol: slightly soluble, PBS (pH 7.2): slightly soluble. SMILES: [O-]C([C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O)=O.[Ca+2].O.O.O.O. InChi Code: InChI=1S/C6H10O8.Ca.4H2O/c7-1(3(9)5(11)12)2(8)4(10)6(13)14,,,,,/h1-4,7-10H,(H,11,12)(H,13,14),,4*1H2/q,+2,,,,/p-2/t1-,2-,3-,4+,,,,,/m0...../s1. InChi Key: ZQWFSIZRQANUDA-WQMSYZFBSA-L.