Calcipotriol (hydrate)

Calcipotriol (hydrate) is a low-calcemic vitamin D receptor (VDR) agonist. Calcipotriol (hydrate) is about 200 times less potent in its effects on calcium metabolism than vitamin D (1,25[OH]D3). Binding of calcipotriol (hydrate) to the VDR increases AP-1, a transcription factor important for keratinocyte differentiation, and reduces expression of JunB protein, a transcriptional activator in the inflammatory response. Calcipotriol (hydrate) also induces expression of thymic stromal lymphopoietin, which triggers T-cell differentiation in keratinocytes.Formal Name: 24-cyclopropyl-(1alpha,3beta,5Z,7E,22E,24S)-9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol, monohydrate. CAS Number: 147657-22-5. Synonyms: Calcipotriene. Molecular Formula: C27H40O3 . H2O. Formula Weight: 430.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, Ethanol:PBS (pH 7.2)(1:5): 0.15 mg/ml. lambdamax: 264 nm. SMILES: C=C1[C@@H](O)C[C@H](O)C/C1=C/C=C2CCC[C@@]3(C)[C@@]\2([H])CC[C@]3([H])[C@H](C)/C=C/[C@@H](O)C4CC4.O. InChi Code: InChI=1S/C27H40O3.H2O/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2,/h6-7,10,13,17,20,22-26,28-30H,2,4-5,8-9,11-12,14-16H2,1,3H3,1H2/b13-6+,19-7+,21-10-,/t17-,22-,23-,24+,25-,26+,27-,/m1./s1. InChi Key: XBKHACNRWFKJNC-MANNPBRJSA-N.