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CAIX inhibitor S4 is an inhibitor of carbonic anhydrase IX (CAIX, Ki = 0.007 µM for the recombinant human enzyme). It is selective for CAIX over CAI and CAII but does inhibit CAXII (Kis = 5.6, 0.55, and 0.002 µM, respectively). CAIX inhibitor S4 inhibits proliferation of HT-29 and MDA-MB-231, but not HCT116, cancer cells under anoxic conditions (IC50s = 20, 481, and >1,000 µM, respectively). CAIX inhibitor S4 (10 mg/kg, i.p.) reduces the number of lung metastases, but not primary tumor growth, in an MDA-MB-231 mouse xenograft model.Formal Name: sulfamic acid, 4-[[[(3,5-dimethylphenyl)amino]carbonyl]amino]phenyl ester. CAS Number: 1330061-67-0. Molecular Formula: C15H17N3O4S. Formula Weight: 335.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 30 mg/ml, Methanol: soluble. SMILES: CC1=CC(C)=CC(NC(NC2=CC=C(OS(N)(=O)=O)C=C2)=O)=C1. InChi Code: InChI=1S/C15H17N3O4S/c1-10-7-11(2)9-13(8-10)18-15(19)17-12-3-5-14(6-4-12)22-23(16,20)21/h3-9H,1-2H3,(H2,16,20,21)(H2,17,18,19). InChi Key: HGVHSNXRZYOTPD-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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