Caffeic acid

Caffeic Acid is an endogenous phenolic phytochemical compound that inhibits a number of lipoxygenases such as 5-LO (5-lipoxygenase), in a non-competitive manner, and 12-LO (12-lipoxygenase) inhibiting leukotriene synthesis involved in immunoregulation, inflammation and allergy. Caffeic acid has antioxidant, immunomodulatory, antiviral, anti-inflammatory, neuroprotective anti-proliferative and anticancer activity. Caffeic Acid has also been shown to inhibit arachidonic acid metabolism in platelets and to stimulate prostaglandin synthesis at high doses. Caffeic Acid is an inhibitor of GST, ODC, Tyk, Fyn kinase and xanthine oxidase. Caffeic acid has been used as a standard of phenolic acid in the study to determine the total phenolic acid content in vegetables after subjecting to alkaline and acid hydrolysis. Product References: (1) Y. Koshihara, et al., Biochim. Biophys. Acta 792, 92 (1984) , (2) N. Kohyama, et al., Biosci. Biotechnol. Biochem. 61, 347 (1997) , (3) I. Shureiqi, et al., J. Natl. Cancer Inst. 92, 1136 (2000) , (4) F.M. da Cunha, et al., Free Radic. Res. 38, 1241 (2004) , (5) F. Bailly, et al., Curr. Med. Chem. 12, 1811 (2005) , (6) N.J. Kang, et al., Carcinogenesis 30, 321 (2009) , (7) K.M.M. Espindola, et al., Front. Oncol. 9, 541 (2009) (Review) , (8) N. Rajendra Prasad, et al., Mol. Cell Biochem. 349, 11 (2011) , (9) M. Touaibia, et al., Mini Rev. Med. Chem. 11, 695 (2011) (Review) , (10) S. Lee, et al., PLoS One 9, e87708 (2014) , (11) F.A. Khan, et al., J. Food Drug Anal. 24, 695 (2016) (Review) , (12) S. Habtemariam, Mini Rev. Med. Chem. 17, 667 (2017) (Review) Appearance: White to light yellow powder. Solubility: Soluble in ethanol (20mg/ml) or DMSO (10mg/ml). Identity: Determined by 1H-NMR. InChi Key: QAIPRVGONGVQAS-DUXPYHPUSA-N Smiles: OC1=C(O)C=CC(/C=C/C(O)=O)=C1