c-Kit-IN-1

c-Kit-IN-1 is a dual inhibitor of c-Kit and c-MET (IC50s = 50s = 50 = <0.2 µM).Formal Name: N-[2,5-difluoro-4-[[2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]phenyl]-N'-phenyl-1,1-cyclopropanedicarboxamide. CAS Number: 1225278-16-9. Molecular Formula: C26H21F2N5O3. Formula Weight: 489.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.1 mg/ml, DMSO: 14 mg/ml, Ethanol: Partially soluble. lambdamax: 250 nm. SMILES: CN(N=C1)C=C1C2=NC=CC(OC3=C(F)C=C(NC(C4(CC4)C(NC5=CC=CC=C5)=O)=O)C(F)=C3)=C2. InChi Code: InChI=1S/C26H21F2N5O3/c1-33-15-16(14-30-33)21-11-18(7-10-29-21)36-23-13-19(27)22(12-20(23)28)32-25(35)26(8-9-26)24(34)31-17-5-3-2-4-6-17/h2-7,10-15H,8-9H2,1H3,(H,31,34)(H,32,35). InChi Key: WWOXKWLDMLMYQY-UHFFFAOYSA-N.