BzATP (triethylammonium salt)

The P2X purinergic receptors are ligand-gated ion channels that are activated by extracellular ATP. BzATP (ammonium salt) is an activator of the P2X receptors that exhibits 5-30-fold greater potency at the P2X7 receptor than ATP. It activates the human, rat, and mouse receptors with EC50 values of 0.7, 3.6, and 285 µM, respectively. BzATP is not selective for P2X7 as it can potently activate other P2X receptors, but without the marked superiority to ATP as an agonist. BzATP can also be used as a photoaffinity probe to study adenine nucleotide binding to ATPases.Formal Name: adenosine 5'-(tetrahydrogen triphosphate), 3'-(4-benzoylbenzoate), compd. with N,N-diethylethanamine (1:1). Molecular Formula: C24H24N5O15P3 . C6H15N. Formula Weight: 816.6. Purity: >75% (mixture of regioisomers). Formulation: (Request formulation change), A solid. Solubility: DMSO: 14 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 257 nm. SMILES: O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@H]1OC(C4=CC=C(C(C5=CC=CC=C5)=O)C=C4)=O.CCN(CC)CC. InChi Code: InChI=1S/C24H24N5O15P3.C6H15N/c25-21-17-22(27-11-26-21)29(12-28-17)23-19(31)20(16(41-23)10-40-46(36,37)44-47(38,39)43-45(33,34)35)42-24(32)15-8-6-14(7-9-15)18(30)13-4-2-1-3-5-13,1-4-7(5-2)6-3/h1-9,11-12,16,19-20,23,31H,10H2,(H,36,37)(H,38,39)(H2,25,26,27)(H2,33,34,35),4-6H2,1-3H3/t16-,19-,20-,23-,/m1./s1. InChi Key: HVOVBTNCGADRTH-WBLDMZOZSA-N.