BX-430

BX-430 is a noncompetitive allosteric antagonist of the purinergic P2X4 receptor (IC50s = 0.54 and 1.89 µM for the human and Xenopus receptors, respectively). BX-430 is selective for the human P2X4 receptor over the human P2X1, P2X2, P2X5, P2X3, and P2X7 receptors at 5 µM and over mouse and rat P2X4 receptors at 10 µM.Formal Name: N-[2,6-dibromo-4-(1-methylethyl)phenyl]-N'-3-pyridinyl-urea. CAS Number: 688309-70-8. Synonyms: Blocker of P2X4 Compound 3.0. Molecular Formula: C15H15Br2N3O. Formula Weight: 413.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 30 mg/ml. SMILES: CC(C1=CC(Br)=C(NC(NC2=CN=CC=C2)=O)C(Br)=C1)C. InChi Code: InChI=1S/C15H15Br2N3O/c1-9(2)10-6-12(16)14(13(17)7-10)20-15(21)19-11-4-3-5-18-8-11/h3-9H,1-2H3,(H2,19,20,21). InChi Key: JFNKIJKRXKPQCC-UHFFFAOYSA-N.