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![BV6](https://www.biomol.com/media/image/a9/0b/20/Cay28830-1_600x600.png)
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
BV6 is a bivalent Smac mimetic and an antagonist of the inhibitor of apoptosis (IAP) proteins... more
Product information "BV6"
BV6 is a bivalent Smac mimetic and an antagonist of the inhibitor of apoptosis (IAP) proteins that binds to IAP1 and XIAP (Kds = 0.46 and 1.3 nM, respectively). It induces autoubiquitination and proteasomal degradation of IAP1 and XIAP in MDA-MB-231 cells when used at a concentration of 5 µM. BV6 (4 µM) induces NF-kappaB activation and TNF-dependent apoptosis in A2058 and MDA-MB-231 cells. It enhances radiosensitization and increases apoptosis in HCC193 and H460 non-small cell lung cancer (NSCLC) cell lines. BV6 (1 µM) induces cell death in a panel of 40 primary, patient-derived B cell precursor acute lymphoblastic leukemia (BCP-ALL) samples in a TNF-dependent manner. In vivo, BV6 (10 mg/kg) increases survival and the time to relapse in a high-risk BCP-ALL patient-derived xenograft (PDX) mouse model.Formal Name: 4,4'-(1,6-hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-beta-phenyl-L-phenylalaninamide. CAS Number: 1001600-56-1. Molecular Formula: C70H96N10O8. Formula Weight: 1205.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 60mg/ml. SMILES: O=C(N[C@@H](C(C1=CC=CC=C1)C2=CC=CC=C2)C(NCCCCCCNC([C@H](C(C3=CC=CC=C3)C4=CC=CC=C4)NC([C@@H]5CCCN5C([C@H](C6CCCCC6)NC([C@@H](NC)C)=O)=O)=O)=O)=O)[C@@H]7CCCN7C([C@H](C8CCCCC8)NC([C@@H](NC)C)=O)=O. InChi Code: InChI=1S/C70H96N10O8/c1-47(71-3)63(81)75-59(53-37-21-11-22-38-53)69(87)79-45-27-41-55(79)65(83)77-61(57(49-29-13-7-14-30-49)50-31-15-8-16-32-50)67(85)73-43-25-5-6-26-44-74-68(86)62(58(51-33-17-9-18-34-51)52-35-19-10-20-36-52)78-66(84)56-42-28-46-80(56)70(88)60(54-39-23-12-24-40-54)76-64(82)48(2)72-4/h7-10,13-20,29-36,47-48,53-62,71-72H,5-6,11-12,21-28,37-46H2,1-4H3,(H,73,85)(H,74,86)(H,75,81)(H,76,82)(H,77,83)(H,78,84)/t47-,48-,55-,56-,59-,60-,61-,62-/m0/s1. InChi Key: DPXJXGNXKOVBJV-YLOPQIBLSA-N.
Keywords: | 4,4'-(1,6-hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-beta-phenyl-L-phenylalaninamide |
Supplier: | Cayman Chemical |
Supplier-Nr: | 28830 |
Properties
Application: | IAP inhibitor, Bivalent Smac mimetic |
MW: | 1205.6 D |
Formula: | C70H96N10O8 |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 1001600-56-1| Matching products |
KEGG ID : | K10522 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H302, H315, H319, H335 |
P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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