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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay30046-1 | 1 mg | - |
6 - 10 business days* |
458.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Budesonide-d8 is intended for use as an internal standard for the quantification of budesonide... more
Product information "Budesonide-d8"
Budesonide-d8 is intended for use as an internal standard for the quantification of budesonide (Cay-15407) by GC- or LC-MS. Budesonide is a glucocorticoid and an agonist of glucocorticoid receptors (EC50 = 45.7 pM in a transactivation assay). It is selective for glucocorticoid over mineralocorticoid receptors (EC50 = 7,620 pM). Budesonide inhibits LPS-induced TNF-alpha release from human peripheral blood mononuclear cells (PBMCs, IC50 = 0.96 nM). It reduces levels of IL-1beta and eotaxin in the lungs and the number of eosinophils and neutrophils in bronchoalveolar lavage fluid (BALF) in a rat model of ovalbumin-induced airway inflammation when administered at a dose of 3 mg/kg. Intracolonic administration of budesonide decreases colon wet weight and colonic myeloperoxidase (MPO) activity in a rat model of oxazolone-induced colitis. Formulations containing budesonide have been used in the treatment of Crohn's disease, ulcerative colitis, allergic rhinitis, and asthma.Formal Name: (11beta,16alpha)-16,17-[butylidene-1,2,2,3,3,4,4,4-d8-bis(oxy)]-11,21-dihydroxy-pregna-1,4-diene-3,20-dione. CAS Number: 1105542-94-6. Molecular Formula: C25H26D8O6. Formula Weight: 438.6. Purity: >99% deuterated forms (d1-d8). Formulation: (Request formulation change), A solid. Solubility: Dichloromethane: slightly soluble, DMSO: slightly soluble. SMILES: C[C@@]12C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@]5([H])[C@@]4(C(CO)=O)OC(C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])([2H])O5)=CC(C=C1)=O. InChi Code: InChI=1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21?,22+,23-,24-,25+/m0/s1/i1D3,4D2,5D2,21D. InChi Key: VOVIALXJUBGFJZ-SMANYZGRSA-N.
Keywords: | (11beta,16alpha)-16,17-[butylidene-1,2,2,3,3,4,4,4-d8-bis(oxy)]-11,21-dihydroxy-pregna-1,4-diene-3,20-dione |
Supplier: | Cayman Chemical |
Supplier-Nr: | 30046 |
Properties
Application: | GC-MS, LC-MS, internal standard, quantification, glucocorticoid receptor agonist |
MW: | 438.6 D |
Formula: | C25H26D8O6 |
Purity: | >99% deuterated forms (d1-d8) |
Format: | Solid |
Database Information
CAS : | 1105542-94-6| Matching products |
KEGG ID : | K05771 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
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H Phrases: | H315, H319, H336, H360, H373, H303 |
P Phrases: | P201, P202, P260, P261, P264, P271, P280, P312, P314, P321, P302+P352, P304+P340, P305+P351+P338, P308+P313, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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