BT2
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: BT2, a BCKDC kinase (BDK) inhibitor, exhibits an IC50 of 3.19 µM and functions as a... more
Product information "BT2"
Description: BT2, a BCKDC kinase (BDK) inhibitor, exhibits an IC50 of 3.19 µM and functions as a potent, selective Mcl-1 inhibitor with a Ki value of 59 µM. Its interaction with BDK induces helix movements in the N-terminal domain, leading to BDK's dissociation from the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC). Target: BCL. Smiles: OC(=O)c1sc2cc(Cl)ccc2c1Cl. References: Tso SC, et al. Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain alpha-ketoacid dehydrogenase kinase. J Biol Chem. 2014 Jul 25,289(30):20583-93.
| Supplier: | TargetMol |
| Supplier-Nr: | T14834 |
Properties
| Application: | Mcl-1 inhibitor |
| MW: | 247.1 D |
| Formula: | C9H4Cl2O2S |
Database Information
| CAS : | 34576-94-8| Matching products |
| KEGG ID : | K02539 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H319, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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