Bromocriptine (mesylate)

Bromocriptine is a dopamine receptor agonist (Kis = 1,659, 12.2, 12.2, 59.7, and 1,691 nM for dopamine D1, D2, D3, D4, and D5 receptors, respectively). It also binds to the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1D (Kis = 12.9 and 10.7 nM, respectively), as well as alpha1-adrenergic receptors (Kis = 1.12-4.17 nM). Bromocriptine (5 mg/kg) restores locomotor activity, without inducing dyskinesia, in a macaque model of Parkinson's disease induced by MPTP. Formulations containing bromocriptine have been used in the treatment of Parkinson's disease, hyperprolactinemia-associated dysfunctions, and acromegaly.Formal Name: (5alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-errgotaman-3',6',18-trione, monomethanesulfonate. CAS Number: 22260-51-1. Synonyms: CB-154. Molecular Formula: C32H40BrN5O5 . CH3SO3H. Formula Weight: 750.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml, Ethanol: 5 mg/ml. lambdamax: 304 nm. SMILES: O[C@@]([C@@](CCC1)([H])N1C2=O)(O[C@@]3(C(C)C)NC([C@@H](CN(C)[C@]4([H])C5)C=C4C6=C7C5=C(Br)NC7=CC=C6)=O)N([C@H]2CC(C)C)C3=O.CS(=O)(O)=O. InChi Code: InChI=1S/C32H40BrN5O5.CH4O3S/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)30(41)31(43-32,17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)15-18,1-5(2,3)4/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39),1H3,(H,2. InChi Key: NOJMTMIRQRDZMT-GSPXQYRGSA-N.