BRL 44408 Maleate Salt

Description: BRL 44408 Maleate Salt is a selective alpha2A-adrenoceptor antagonist with Ki value of 1.7 nM. BRL 44408 Maleate Salt increases the release of hippocampal noradrenalin following systemic administration. Target: Others. Smiles: C(=C\C(O)=O)\C(O)=O.CC1C=2C(CN1CC=3NCCN3)=CC=CC2. References: Dwyer JM, Platt BJ, Rizzo SJ, Pulicicchio CM, Wantuch C, Zhang MY, Cummons T, Leventhal L, Bender CN, Zhang J, Kowal D, Lu S, Rajarao SJ, Smith DL, Shilling AD, Wang J, Butera J, Resnick L, Rosenzweig-Lipson S, Schechter LE, Beyer CE. Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism. Int J Neuropsychopharmacol. 2010 Oct,13(9):1193-205. doi: 10.1017/S1461145709991088. PubMed PMID: 20047711.