Brevetoxin 3
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Larger quantity required? Request bulk
Brevetoxins are lipid-soluble polyether neurotoxins produced by the dinoflagellate Karenia... more
Product information "Brevetoxin 3"
Brevetoxins are lipid-soluble polyether neurotoxins produced by the dinoflagellate Karenia brevis. Brevetoxins act as agonists, binding the neurotoxin site 5 on SCN4A/Nav1.4 and SCN5A/Nav1.5 voltage-gated Na+ channels in skeletal muscle and cardiac tissue, producing a channel opening effect, this activity results in bronchoconstriction and airway inflammation in vivo. Stimulation of the voltage-gated Na+ channels also induces NMDA receptor-mediated release of L-glutamate and L-aspartate in neurons. Brevetoxin 3 is a type B brevetoxin and a metabolite of brevetoxin 2.
| Keywords: | PbTx-3 |
| Supplier: | LKT Laboratories |
| Supplier-Nr: | B6918 |
Properties
| Application: | SCN4A/Nav1.4 / SCN5A/Nav1.5 agonist |
| MW: | 897.2 D |
| Purity: | >95% |
| Format: | Solid |
Database Information
| CAS : | 85079-48-7| Matching products |
| KEGG ID : | K04837 | Matching products |
Handling & Safety
| Storage: | +20°C |
| Shipping: | +20°C (International: +20°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H300, H310, H330 |
| P Phrases: | P260, P262, P264, P270, P271, P280, P284, P301+P310, P302+P352, P304+340, P310, P312, P320, P330, P361, P363, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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