Brevetoxin 3

Brevetoxin 3 is a neurotoxin produced by the dinoflagellate K. brevis. It binds to site 5 of voltage-gated sodium channels (Navs), prolonging the mean open time and inhibiting inactivation of these channels. Brevetoxin 3 induces the release of lactate dehydrogenase (LDH), L-glutamate, and L-aspartate from primary rat cerebellar granule neurons (CGNs, EC50s = 30.9, 45.3, and 50.2 nM, respectively). It induces convulsions in, and is lethal to (LD50 = 4 ng/egg), Japanese rice fish embryos. Brevetoxin 3 has been found in water samples collected during red tide blooms.Formal Name: 42-deoxo-42-hydroxy-brevetoxin B. CAS Number: 85079-48-7. Synonyms: PbTx-3, T-17 Toxin. Molecular Formula: C50H72O14. Formula Weight: 897.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: C[C@@]12[C@](C[C@@]3([H])[C@](O2)(CC[C@@]4([H])[C@]([C@@H](C[C@@]5([H])[C@](C[C@]6([C@](C[C@@]7([H])[C@](C(C)=CC(O7)=O)([H])O6)([H])O5)C)([H])O4)C)([H])O3)C)([H])O[C@@]8([C@@](O[C@]9([H])[C@@](O[C@]%10([H])[C@@](O[C@@]%11([C@@](O[C@@H](C[C@@H]%11O)CC(CO)=C)([H])C%10)C)([H])C9)([H])C=CC8)([H])C1)C. InChi Code: InChI=1S/C50H72O14/c1-25(24-51)14-28-17-37(52)50(8)41(54-28)19-33-34(61-50)18-32-29(55-33)10-9-12-46(4)42(58-32)23-49(7)40(62-46)21-39-47(5,64-49)13-11-30-44(60-39)26(2)15-31-36(56-30)22-48(6)38(57-31)20-35-45(63-48)27(3)16-43(53)59-35/h9-10,16,26,28-42,44-45,51-52H,1,11-15,17-24H2,2-8H3/t26-,28-,29-,30+,31+,32+,33+,34-,35+,36-,37+,38-,39+,40-,41-,42-,44-,45-,46+,47-,48+,49+,50+/m1/s1. InChi Key: BKMHDYJRAAJTAD-RXUQWMQDSA-N.